In vivo NMR and MRI using injection delivery of laser-polarized xenon

TitleIn vivo NMR and MRI using injection delivery of laser-polarized xenon
Publication TypeJournal Article
Year of Publication1997
AuthorsGoodson B.M, Song Y.Q, Taylor R.E, Schepkin V.D, Brennan K.M, Chingas G.C, Budinger T.F, Navon G., Pines A
JournalProceedings of the National Academy of Sciences of the United States of America
Volume94
Issue26
Pagination14725-14729
Date PublishedDec 23
ISBN Number0027-8424
Accession NumberWOS:000071182800090
Keywordshumans
Abstract

Because xenon NMR is highly sensitive to the local environment, laser-polarized xenon could be a unique probe of living tissues. Realization of clinical and medical science applications beyond lung airspace imaging requires methods of efficient delivery of laser-polarized xenon to tissues, because of the short spin-lattice relaxation times and relatively low concentrations of xenon attainable in the body. Preliminary results from the application of a polarized xenon injection technique for in vivo Xe-129 NMR/MRI are extrapolated along with a simple model of xenon transit to show that the peak local concentration of polarized xenon delivered to tissues by injection may exceed that delivered by respiration by severalfold.

URL<Go to ISI>://WOS:000071182800090
DOI10.1073/Pnas.94.26.14725
Short TitleIn vivo NMR and MRI using injection delivery of laser-polarized xenon
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